hla-cw allele frequency in definite meniere’s disease compared to probable meniere’s disease and healthy controls in an iranian sample

نویسندگان

sasan dabiri otorhinolaryngology research center, amiralam hospital, tehran university of medical sciences, tehran, iran

fatemeh ghadimi otorhinolaryngology research center, amiralam hospital, tehran university of medical sciences, tehran, iran

mohammadreza firouzifar otorhinolaryngology research center, amiralam hospital, tehran university of medical sciences, tehran, iran

nasrin yazdani otorhinolaryngology research center, amiralam hospital, tehran university of medical sciences, tehran, iran

چکیده

introduction several lines of evidence support the contribution of autoimmune mechanisms in the pathogenesis of meniere’s disease. the aim of this study was determining the association between hla-cw alleles in patients with definite meniere’s disease and patients with probable meniere’s disease and a control group.  materials and methods: hla-cw genotyping was performed in 23 patients with definite meniere’s disease, 24 with probable meniere’s disease, and 91 healthy normal subjects, using sequence specific primers polymerase chain reaction technique. the statistical analysis was performed using stata 8 software.  results: there was a significant association between hla-cw*04 and hla-cw*16 in both definite and probable meniere’s disease compared to normal healthy controls. we observed a significant difference in hla-cw*12 frequencies between patients with definite meniere’s disease compared to patients with probable meniere’s disease (p=0.04). the frequency of hla-cw*18 is significantly higher in healthy controls (p=0.002).  conclusion: our findings support the rule of hla-cw alleles in both definite and probable meniere’s disease. in addition, differences in hla-cw*12 frequency in definite and probable meniere’s disease in our study’s population might indicate distinct immune and inflammatory mechanisms involved in each condition.

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HLA-Cw Allele Frequency in Definite Meniere’s Disease Compared to Probable Meniere’s Disease and Healthy Controls in an Iranian Sample

Introduction Several lines of evidence support the contribution of autoimmune mechanisms in the pathogenesis of Meniere’s disease. The aim of this study was determining the association between HLA-Cw Alleles in patients with definite Meniere’s disease and patients with probable Meniere’s disease and a control group.  Materials and Methods: HLA-Cw genotyping was performed in 23 patients with def...

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عنوان ژورنال:
iranian journal of otorhinolaryngology

جلد ۲۸، شماره ۴، صفحات ۲۶۱-۲۶۶

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